"Glucosamine for Migraine Prophylaxis?" Russell AL, McCarty MF, Med Hypotheses, 2000;55(3):195-198.
An anecdotal case report of a female with osteoarthritis who received glucosamine at 500 mg, 3 times daily, noted that she had relief of her migraine headaches for the first time in 20 years while on the medication, even though it did not help her osteoarthritic pain. After this case report, the author gave glucosamine at 500 to 1,500 mg, 3 times daily, to 10 other patients with therapy-refractory migraine or migraine-like headaches and noticed after 4 to 6 weeks, there was a significant reduction in the frequency and/or intensity of headaches noted. In some cases, the relief was dose-dependent, providing relief only after the initial dose of 500 mg, 3 times daily, was increased. There were no adverse side effects noted after the 6-month observation period. The authors believe that supplemental glucosamine may enhance mast cell heparin synthesis, possibly correcting a functional heparin deficiency, which may have an antiinflammatory effect and prevent neurogenic inflammation that might cause the pain in vascular headache.
(Editors Note: If you suffer with migraine headaches, this is very interesting and worthy of a trial. Please send us your feedback using the following link :e-mail)